GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs1768803 | chr1:46546208 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.22 | 1.28E-9 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs1768803 | chr1:46546208 | MUTYH | chr1:45794915-45806142:- | 0.2 | 3.9 | 0.000115 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs1768816 | chr1:46528599 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.31 | 7.74E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs1768816 | chr1:46528599 | MUTYH | chr1:45794915-45806142:- | 0.2 | 3.89 | 0.000117 | Body mass index |
| BLCA | cis | rs10935120 | 1 | rs17694011 | chr3:134213981 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.74 | 8.8E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs17694011 | chr3:134213981 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 4.02 | 7.02E-5 | Height |
| BLCA | cis | rs17694493 | 1 | rs17694493 | chr9:22041998 | CDKN2A | chr9:21967752-21994490:- | 0.31 | 4.62 | 5.37E-6 | Prostate cancer |
| BLCA | cis | rs17694493 | 1 | rs17694493 | chr9:22041998 | CDKN2B | chr9:22002906-22009312:- | 0.32 | 4.77 | 2.67E-6 | Prostate cancer |
| BLCA | cis | rs17694493 | 1 | rs17694493 | chr9:22041998 | KLHL9 | chr9:21324054-21335429:- | 0.3 | 4.28 | 2.41E-5 | Prostate cancer |
| BLCA | cis | rs60843830 | 1 | rs17713396 | chr2:227201 | SH3YL1 | chr2:218138-264810:- | -0.43 | -11.03 | 9.8E-25 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs17713729 | chr2:249092 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.8 | 1.3E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs17714252 | chr2:285471 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.64 | 5.13E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs7714584 | 1 | rs17727568 | chr5:150244688 | LOC134466 | chr5:150310000-150326146:- | 0.54 | 6.45 | 3.38E-10 | Crohn's disease |
| BLCA | cis | rs1775148 | 1 | rs1775148 | chr1:205757824 | PM20D1 | chr1:205797154-205819245:- | -0.26 | -4.85 | 1.79E-6 | Prostate cancer |
| BLCA | cis | rs1775148 | 1 | rs1775148 | chr1:205757824 | RAB7L1 | chr1:205737115-205744610:- | 0.36 | 5.82 | 1.22E-8 | Prostate cancer |